Allergic contact dermatitis due to 8-MOP is a rarely known side effect of this widely used drug. Other known adverse reactions due to 8-MOP such as photoallergic dermatitis as well as some isolated cases of exanthema, papular eruptions, and
asthma
like
symptoms are also sporadically reported.
A 52-year-old man with vitiligo developed erythema to the UVA exposed 0.3% OxoralenR cream applied area. Prior to this episode, the patient had history of generalized burns after systemic PUVA therapy in 1983. Even after this experience, the
patient had
few more episodes of erythema at the site of 0.3% Oxoralen(r) cream application. We performed patch test and photopatch tests with Scandinavian series, 0.3% Oxoralen(r) cream (as is), and diluted 8-MOP, 5-MOP, TMP solution. The result showed
positive
reactivity to 6-methylcoumarin, 8-MOP, as well as to 0.3% Oxoralen(r) cream. The size of erythema was same in both irradiated areas which indicates an allergic contact dermatitis rather than photoallergic dermatitis or phototoxic dermatitis. (Kor
J
Dermatol 1992;30(6):897-900)
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